12月23日(月)「Design and Synthesis of Polymer-Based Cryoprotectants for Frozen Storage of Mammalian Cells」講師:NATHANIEL A. LYND先生

先導研先生方各位

先導研特定プロジェクト教員NATHANIEL A. LYND先生の講演会を下記のように開催致します。
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日 時 : 2019年12月23日(月)15:00-16:30 20191223_講演会プログラムPDFファイルへ

場 所 : 先導研(CE41) 第1セミナー室 A・B


講 師 : NATHANIEL A. LYND先生(Nate先生)先導研特定プロジェクト教員(旧招聘外国人研究員)(University of Texas at Austin, U.S.A.)


演 題 : 「Design and Synthesis of Polymer-Based Cryoprotectants for Frozen Storage of Mammalian Cells」


概 要 :

Polymeric materials provide a low-toxicity, low osmolality, and high functionality alternative to small molecule cryopreservative formulations such as solutions of dimethylsulfoxide (DMSO) or glycerol. Polymers can be designed that are inherently non-toxic and produce high post-thaw recovery of mammalian cells after frozen storage at –196 ºC. In this presentation, I will describe our efforts in the design and synthesis of improved cryoprotective polymeric materials and how design has been guided by investigation of polymer-water-ice-cellular interactions, and also post-thaw viability assays of model cell lines. Significantly, materials have been synthesized that increase the extent of the unfrozen fraction of aqueous solutions upon cooling, and that also affect the kinetics of cellular dehydration during freezing; these factors are believed to be important in affecting polymer-mediated post-thaw recovery of mammalian cells
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連絡先:田中 賢(伊都-6238)先導物質化学研究所 ソフトマテリアル学際化学

Posted:2019/12/18.