November 20, 2020
Seminar Room CE41, IMCE, Kyushu Univ.
With broadcast via ZOOM
Speaker: Prof. Ye Zhang(OIST, Okinawa)
Title: Regulating Cellular Response via Molecular Assembly in Cell Milieu
Abstract: Molecular assembly is a widely applied synthetic strategy for the construction of multimolecular architectures that can simultaneously target numerous components. Upon the control over size, shape, valency, Molecular assembly has fit the demands to modulate proteins, even cell fate by approaching different cellular sub-organelles, including plasma membrane compartments, endoplasmic reticulum, mitochondria, and lysosomes without encountering sophisticated trafficking. We have demonstrated a serious of molecular design for protein-guided molecular assembly targeting plasma membrane compartments; self-delivered molecular assembly targeting endoplasmic reticulum, etc. Recently, we also developed a molecular assembly system that could self-adjust morphologically to trespass Golgi-endosome trafficking, escape from trafficking cargos targeting microtubule arrays, which demonstrates the might of synthetic molecular assembly via control of cancer cell cycle. We also identified that sub-organelle-targeted molecular assembly is applicable in combination therapy with promising outcome in cancer treatment.
About Speaker: Ye Zhang received BS in Chemistry from Nankai University, and Ph.D. in Organic Chemistry from Hong Kong University of Science and Technology, China. After doing postdoctoral research on active soft matter in Prof. Bing Xu’s lab at Brandeis University, USA, she joined OIST as independent PI leading Bioinspired Soft Matter Unit in 2015. Her research focuses on development of bottom-up nano-biointerface fabrication technology that generates nanoscale protein activity at specific sub-cellular areas, which then link directly to microscale biological activities with applications in cancer research and regenerative medicines.
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